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User Profile Cant be loaded

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Recently we stat to get an issue with our Internal Network workstations ( not accessible from internet physically and logically).
the error message start to appear on Windows 7 workstations, during the first days the error was reported from about or 1 or 2 workstations daily but now the issue is happening on windows 10 & Windows 7 and the calls are becoming about 5 to 8 calls per days.
the error message  “ The User Profile Service service failed the login. User profile can’t be loaded “
We fix the problem by overwriting the default profile folder for the workstation from another working one, but we don't have an explanation why the problem is happening and why its spreading everywhere.
 
Notes :-
1-the  problem is happening on Windows 10 and Windows 7 workstations with different build versions  and different  PC hardware models.
2- we are using Mcafee antivirus with latest daily update (downloaded and pushed offline) and the path for default profile has been excluded from scanning  for troubleshooting reason.
3-When we check infected workstation we found error regard network disconnect and then follows by not applying GPs on that workstations
4-We are using a local profile kindly for our domain users.
5- When we check infected workstation we found error regard network disconnect and then follows by not applying GPs on that workstations
 
last changes before problem happening:-
1-     Applied password policy ( group policy ) and apply it on domain level. (Working currently)
2-     Pushed Internet explorer 11 ( upgrade ) for windows 7 only through SCCM 2012R2SP1
3-     Configured antivirus policy to block Temp folder,
 
We did the following steps to troubleshoot the issue:
1-     Stopped pushing IE11 deployment.
2-     Remove antivirus policy to block Temp folder.
3-     Stop scanning Users folder through antivirus (MacAfee)
 
But the issue still exist and keep increasing. Recently windows 10 have that issue as well. Event IDs are as follows:
1-     1509   (source: user profile general)

2-     1534   (source: user profile general)

On infected computers, we followed  one Microsoft article, but the path on the mentioned folder was not exist on most of those computers (windows7 only), so the user’s profile issue is not occurring because updating IE:


What else we can do to find out the cause of this issue.

Best Regards,



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