Set-up AD on windows server 2012r2

hi,

So I am on a mission to install AD on windows server 2012r2 Standard.

Current set-up is that we have 3 AD's with Windows 2008r2 between 3 sites running on HP ProLiant 360.

New Server is HP Proliant 380 with Windows 2012r2. Would it be difficult to set-up AD on this server and would it cause any compatibility issues considering other servers are running windows 2008 r2 and likely older AD environment? 

MK