Reset Directory Permissions With DSACLS With Exchange 2010 & Lync 2013

I've taken over directory administration and combing through permissions on the tree and then are way out of whack.  I wanted to know if it's safe to use the DSACLS program to reset the permissions when we have Exchange 2010 and Lync 2013 installed.

I did some spelunking through the default permissions on some of the classes in the Schema and it didn't look like Exchange or Lync permissions were there so I figured it might not be safe but thought I'd check with people who probably know better.

Regarding the Exchange and Lync permissions, and as an example, the root node has Exchange Enterprise Servers, Exchange Servers, Exchange Recipient Administrators, Exchange Trusted Subsystem, RTCUniversalServerReadOnlyGroup, RTCUniversalUserAdmins, etc

I figure DSACLS isn't going to replace all those if I reset permissions with it.

Thanks!